Car-T Platform

CAR-T (Chimeric Antigen Receptor T-cell) therapy is a groundbreaking advancement in cancer treatment. This innovative therapy involves modifying a patient’s T-cells, enabling them to target and destroy cancer cells. It has shown remarkable success in treating hematological malignancies, including lymphomas and leukemias​​.

Key Features of CAR-T Platform

  1. Autologous Therapy: Patient-derived T-cells are genetically engineered to target specific cancer antigens like CD19 or BCMA, ensuring precision treatment tailored to individual patients​​.
  2. Advanced Manufacturing Workflow: From T-cell collection through leukapheresis to genetic modification, expansion, and cryopreservation, each step adheres to stringent GMP standards. Technologies like the Sefia™ Select system streamline automation and reduce contamination risks​​.
  3. State-of-the-Art Equipment: Solutions like Sepax™ C-Pro for cell processing, Xuri™ systems for cell expansion, and VIA Freeze™ for cryopreservation ensure consistent quality and reproducibility​​.



Benefits of the Platform

  • Personalized Therapy: Tailored treatments based on the patient’s unique cancer profile.
  • Regulatory Compliance: Functionally closed systems like Cytiva’s Sefia meet FDA and EU Annex 11 requirements, ensuring data integrity and patient safety​​.
  • Collaborative Ecosystem: Partnerships with global leaders like Cytiva and Pall enable access to cutting-edge technologies and expertise​​.

Applications in Turkey
TCT Sağlık is spearheading efforts to bring CAR-T therapies to Turkey, focusing on technology transfer, local production, and establishing fully integrated FlexFactory™ centers. These initiatives aim to make advanced cell therapies more accessible, contributing to Turkey’s biotechnology ecosystem​​.

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